Parallel Profiling of DNA and Transient Epigenomic Solution

Parallel Profiling of DNA and Transient Epigenomic

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Parallel Profiling of DNA and Transient Epigenomic

I'm working on a biology question and need an explanation to help me study.

Which of the following statements is TRUE concerning an orphan nuclear receptor?

Group of answer choices

– It is a protein that transcribes unknown genes.

– It is a transmembrane protein that signals to the nucleus to transcribe unknown genes.

– It is a protein that binds to an unknown signaling molecule.

– It is a transmembrane protein that signals to the nucleus upon binding an unknown ligand.

Which Protein Pair Would Be Most Effective for Cell 1 to Adhere to Cell 2 Question

I'm working on a biology question and need an explanation to help me study.

Which protein pair would be the most effective for Cell 1 to adhere to Cell 2?

Group of answer choices

– Cadherin on Cell 1 and Cadherin on Cell 2

– Integrin on Cell 1 and Cadherin on Cell 2

– Integrin on Cell 1 and Integrin on Cell 2

– Notch on Cell 1 and Delta on Cell 2

Clustered Regularly Interspaced Short Palindromic Repeats Questions

OVERVIEW

This week we learnt about central dogma of gene expression: “one gene–one protein”

hypothesis, which means one Gene makes one protein (Polypeptide). This is two-step process,

in the first step genetic code stored in DNA transcribed into RNA. In the second steps message

transcribed in RNA is translated into amino acids by Ribosomes. The rules for translation of the

coded message into amino acids are contained in the genetic code. This chain of events is full of

glitches in the form of errors in both the incorporation of nucleotides into RNA and amino acid

incorporation in proteins. Errors in protein synthesis disrupt cellular fitness, cause disease

phenotypes, and shape gene and genome evolution. Gene editing may help to repair errors.

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The 2020 Nobel Prize in Chemistry has gone to Emmanuelle Charpentier and Jennifer A. Doudna

“for the development of a method for genome editing.” That method, formally known as

CRISPR-Cas9 gene editing but often called simply CRISPR, allows scientists to precisely cut any

strand of DNA they wish and repair it. Thus, the new gene-editing tool CRISPR — can make

heritable changes in human embryos. Good part of CRISPR is that it may give us the cure to HIV,

genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even

the most minuscule changes to DNA could have numerous unexpected ethical and societal

consequences and may even have unimaginable power to control evolution.

Watch the video and read the suggested reference to answer the following questions:

What does CRISPR stand for?

Which type of organism’s harbor/contain this system? And what is the CRISPR-Cas9 system

function in those organisms?

For medical applications, provide a guide how the CRISPR-Cas9 can be used to fix gene errors in

cystic fibrosis or any other genetic disorders. (use the video and reference listed below).

Basic mechanism of evolution is gene mutation. Discuss how CRISPR can control evolution

process?

Gene editing using CRISPR-Cas9 is not without ethical dilemma, can you provide an example

where the clinical application of CRISPR-Cas9 can lead to ethical issues? Provide one example.

Parallel Profiling of DNA and Transient Epigenomic

RUBRIC
Excellent Quality 95-100%	Introduction 45-41 points The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned.		Literature Support 91-84  points The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned.			Methodology 58-53 points Content is well-organized with headings for each slide and bulleted lists to group related material as needed. Use of font, color, graphics, effects, etc. to enhance readability and presentation content is excellent. Length requirements of 10 slides/pages or less is met.
Average Score 50-85%	40-38 points More depth/detail for the background and significance is needed, or the research detail is not clear. No search history information is provided.		83-76  points Review of relevant theoretical literature is evident, but there is little integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are included. Summary of information presented is included. Conclusion may not contain a biblical integration.			52-49  points Content is somewhat organized, but no structure is apparent. The use of font, color, graphics, effects, etc. is occasionally detracting to the presentation content. Length requirements may not be met.
Poor Quality 0-45%	37-1 points The background and/or significance are missing. No search history information is provided.		75-1 points Review of relevant theoretical literature is evident, but there is no integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are not included in the summary of information presented. Conclusion does not contain a biblical integration.			48-1 points There is no clear or logical organizational structure. No logical sequence is apparent. The use of font, color, graphics, effects etc. is often detracting to the presentation content. Length requirements may not be met
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