DNA Damage Mechanisms Assignment Discussion

DNA Damage Mechanisms Assignment Discussion

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DNA Damage Mechanisms Assignment Discussion

Dr. Lee’s lab focuses on finding the way to lower the COVID-19 death rate. Previous studies showed that COVID-19 viruses exploit host DNA damage mechanisms to promote viral replication by recruiting host DNA damage proteins to viral replication center. Furthermore, ATM/ATR DNA damage/repair pathways enhanced by this virus-mediated replication stress. Now, this is your research project, please try to find the solution for below questions,

First, we are trying to figure out which type of DNA damage (double-stranded breaks, DSBs or single-stranded breaks, SSBs) may observe in COVID-19 virus-infected host cells (2 points)? Why (6 points)?

If it is DSBs damage accumulated in COVID-19 virus-infected host cells, could you name Two DSBs repair mechanism from our textbook or lectures (2 points)?

Please describe detail steps of BOTH DSBs repair mechanisms at the molecular level, for examples which proteins involved, what is the role of each protein and more (10 points)?

Prokaryotes and Eukaryotes Questions

#1

You have a friend who wants to grow some California native plants in her backyard. She says the seed package recommends soaking the seeds for optimal growth. As a clever biology student, you recommend setting up an experiment to see if soaking the seeds will result in faster growing plants.

How would you do this? What would you include in your control and variable groups? What would your hypothesis be? What kind of reasoning would you use while designing this experiment?

#2

Prokaryotes and Eukaryotes each contain a large diversity of living organisms. These organisms have cellular structures that perform a variety of functions. What Domains include each of these organisms? What cellular structures are similar between cells in Prokaryotes and Eukaryotes? What is the function of each of these structures? Additionally, give three examples of cellular structures that are unique to Eukaryotes and describe in detail what they do.

DNA Damage Mechanisms Assignment Discussion

RUBRIC
Excellent Quality 95-100%	Introduction 45-41 points The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned.		Literature Support 91-84  points The background and significance of the problem and a clear statement of the research purpose is provided. The search history is mentioned.			Methodology 58-53 points Content is well-organized with headings for each slide and bulleted lists to group related material as needed. Use of font, color, graphics, effects, etc. to enhance readability and presentation content is excellent. Length requirements of 10 slides/pages or less is met.
Average Score 50-85%	40-38 points More depth/detail for the background and significance is needed, or the research detail is not clear. No search history information is provided.		83-76  points Review of relevant theoretical literature is evident, but there is little integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are included. Summary of information presented is included. Conclusion may not contain a biblical integration.			52-49  points Content is somewhat organized, but no structure is apparent. The use of font, color, graphics, effects, etc. is occasionally detracting to the presentation content. Length requirements may not be met.
Poor Quality 0-45%	37-1 points The background and/or significance are missing. No search history information is provided.		75-1 points Review of relevant theoretical literature is evident, but there is no integration of studies into concepts related to problem. Review is partially focused and organized. Supporting and opposing research are not included in the summary of information presented. Conclusion does not contain a biblical integration.			48-1 points There is no clear or logical organizational structure. No logical sequence is apparent. The use of font, color, graphics, effects etc. is often detracting to the presentation content. Length requirements may not be met
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DNA Damage Mechanisms Assignment Discussion

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